Anti-Obesity Effects of Punicalagin and Punica granatum Fruit Juice Extract in Adipocytes Differentiated from Human Bone Marrow Mesenchymal Stem Cells

Abstract: Punicalagin (PUN) is an ellagitannin, a type of phenolic compound. It is found as alpha and beta isomers in pomegranates. This study investigates the anti - obesity effects of PUN and pomegranate fruit juice extract on adipocyte differentiation, lipid accumulation, and obesity - related inflammation. The research utilized adipocytes differentiated from human bone marrow - derived mesenchymal stem cells. Results demonstrated that, 50% of the cells were inhibited by treatment with 400 ?M PUN and 1.8 mg/dL pomegranate fruit juice. The expression levels of various genes associated with obesity, such as PPARGC1, UCP - 1, PPARG, and PRDM16, were decreased by treatment with 100 ?M PUN (p ? 0.05). PUN and pomegranate fruit juice inhibited adipocyte differentiation, lipid accumulation, and obesity - related inflammation. In Conclusion, the present findings suggest that PUN and pomegranate fruit juice reduce adipocyte differentiation and lipid accumulation, further suggesting that, they may be role in treatment of obesity.

Keywords: Punicalagin, Pomegranate fruit juice extract, Adipocyte differentiation, Lipid accumulation, Obesity - related inflammation, Mesenchymal stem cells

Edition: Volume 12 Issue 7, July 2023,

Pages: 1575 - 1583