Downloads: 2 | Views: 64 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2

Research Paper | Pharmaceutical Science | India | Volume 12 Issue 10, October 2023

Formulation and Evaluation of Sustained Release Microspheres of Fexofenadine Hydrochloride by Ionotropic Gelation Method

Arunava Biswas

Abstract: This research paper is based on the formulation and evaluation of sustained release polymericmicrospheres of the second-generation, anti-histaminic drug Fexofenadine Hydrochloride. Though fexofenadine hydrochloride is an effective and safer option compared to other antihistaminic drugs available in the market still it is not commonly used in the treatment of seasonal allergic rhinitis due to its less bioavailability and higher cost. The aim of this research was to formulate a novel, effective, efficient and safe drug delivery system for Fexofenadine HCL so that this drug can be made more efficient and cost-effective. The ionotropic gelation method was applied to formulate the microsphere formulations, where sodium alginate, HPMC and pectin were used (in different combinations and ratios) as polymers and calcium chloride was used as a crosslinking agent. Total 6 formulations (FX-1 to FX-6) were formulated and evaluated. Among all the formulations prepared FX-3 was selected as the optimized and final formulation based on the evaluation of all the important parameters. In the final formulation drug: polymer ratio was 1:7 and sodium alginate and HPMC were used as polymers in 1:1 ratio.

Keywords: Fexofenadine Hydrochloride, Microspheres, Ionotropic gelation, Sodium Alginate, HPMC

Edition: Volume 12 Issue 10, October 2023,

Pages: 1474 - 1482