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Research Paper | Obstetrics and Gynecology | India | Volume 12 Issue 6, June 2023
Study of Serum Lipid Profile in Pregnancy and its Association with Pre-Eclampsia
Dr. Jyoti Verma | Dr. Hanslata Gehlot [8] | Dr. Princee Seth | Dr. Kirti Gupta
Abstract: Objective: To study serum lipid profile in third trimester (28 ? 36 weeks) and its relation with pre-eclamptic and normotensive. Material and Methods: We carried out a case control study in the department of Obstetrics and Gynaecology at Umaid Hospital, Dr SN Medical College, Jodhpur from March 2022 to December 2022.Total 230 patients were enrolled in study fulfilling inclusion and exclusion criteria between 28-36 weeks of gestation. Serum lipid profile was done in all patients and they were followed till delivery for presence and absence of preeclampsia. Result: In our study 20.87% of subjects developed pre eclampsia and 79.13% remained normotensive till delivery. Mean total cholesterol value was higher (302.83 mg/dl) in pre eclampsia group than normotensive group (214.6mg/dl).In pre eclampsia group values of Mean Triglycerides(263.97 mg/dl), LDL(194.56 mg/dl)and VLDL(44.56 mg/dl)were raised than Mean Triglycerides(195.26mg/dl), LDL(122.17 mg/dl)and VLDL(31.82 mg/dl) values of normotensive group .Mean HDL level in both pre eclamptic group (60.6 mg/dl) and normotensive group (59.24mg/dl) was almost similar. Conclusion: Pre eclampsia is multisystem, heterogeneous disorder with variable phenotype and enigmatic pathogenesis. Gradual unveiling of pathogenesis by gamut of theories have lead to pulchritude of biomarkers but still unrealistic for developing countries. So, avaricious search for single, feasible, cost effective biomarker is still on. Lipid analysis in early pregnancy may help in prediction of pre eclampsia before it goes berserk. It may serve as simple, cost effective method for prediction of pre eclampsia in developing countries. Lipid profile has evolved as a new kid on the block.
Keywords: Pre-eclampsia, HDOP, lipid profile, pregnant women, cholesterol, triglyceride, primigravida.
Edition: Volume 12 Issue 6, June 2023,
Pages: 2914 - 2919