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Case Studies | Immunology | India | Volume 12 Issue 6, June 2023

A Case Report on COVID-19 Vaccination Induced Heart Failure

Bincy Charley | Reshmi Rajan | Anju K Francis | Minna Sara Philip ^[2] | Dr Anulekha Mary John | Dr Prakash Krishnan

Abstract: Heart failure following the COVID-19 vaccination has been documented as a rare side effect. In this report, we describe the case of a 61-year-old woman with a history of heart disease in her family and previously detected mild atherosclerotic coronary artery disease who, 4 months after receiving her third dose of COVISHIELD vaccination against the COVID-19 virus, developed heart failure with a significantly reduced ejection fraction. Laboratory tests showed increased levels of N-terminal pro-brain natriuretic peptide (NT-proBNP). An ECG was taken, which indicated sinus rhythm (SR) at 114, left bundle branch block (LBBB), and QRS-125. An echocardiogram (ECHO) was done, which revealed Left Ventricular global hypokinesia, LVEF 30% MOD MR RV dysfunction, and dilated LA/RA RV dysfunction. Hence, she was diagnosed with heart failure with reduced ejection fraction (LVEF of 32%) and dilated cardiomyopathy with severe LV dysfunction. She was successfully discharged with advice to follow up regularly and with appropriate medical management. Through this case report, we aim to raise awareness of the potential for the COVID-19 vaccination to trigger certain immunological reactions that could probably lead to heart failure in an already predisposed individual who is at risk of myocardial injury.

Keywords: COVID-19, Heart failure, COVISHIELD, Vaccination

Edition: Volume 12 Issue 6, June 2023,

Pages: 2387 - 2389