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Review Papers | Pharmaceutical Science | India | Volume 12 Issue 9, September 2023
Preparation and Evaluation of Novel Floating Mucoadhesive Antidiabetic Tablets
Pushpa Patiram Harijan | Ran Vijay Singh | Dr. Sanjay Kumar Kushwaha [2]
Abstract: In the present study, Metformin an anti - diabetic drug is formulated in the form of floating mucoadhesive tablets to improve its bioavailability. Various polymers used as rate controlling and mucoadhesive polymers in designing the tablets. Various formulations were prepared by using different concentration of polymers. The pre - compression blend of Metformin mucoadhesive tablets were characterized with respect to bulk density, angle of repose, tapped density, carr?s index and hausner?s ratio and all the results indicated that the blend had good flow property and better compressibility. The swelling studies were performed and the results indicated that all the formulations had good swelling index. The Floating and Mucoadhesive both are coming under the novel drug delivery system in which they considered as predominantly more effective as compared to alternative drug delivery system because this formulation having direct contact with a biological system. This review also describes the studies to assess the effectiveness and implementation of floating systems, and applications of mucoadhesive systems. Regardless of age, diabetes is a complicated group of health conditions that impact many individuals. Researchers from all around the world have looked into and created various drug - delivery methods that try to cure this condition because of how prevalent it is. Current treatments for DM are characterised by shorter half - lives, which means that patients must take bigger dosages daily, which is not ideal. Therefore, medications with extended stomach residence durations need to be designed for continuous release, which can help the drug's effects last longer. For this reason, the medication should stay in the stomach or upper gastrointestinal system for prolonged periods of time.
Keywords: Floating, Bioadhesive, Effervescent, Colloidal system. Mucoadhesive tablets, floating, Mucoadhesive polymer
Edition: Volume 12 Issue 9, September 2023,
Pages: 1856 - 1860