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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 6, June 2023
Design Synthesis and Screening of Mannich Bases of Alliin as Anti - Infective Agents
Sagar Jagtap | Sachin Pishwikar
Abstract: Objective: Alliin is active constituent present in garlic having variouspharmacological activities like antimicrobial, antimalerial, antifungal, anticonvulgent, analgesics and anti - inflammatory type of activity. In alliin form physically it has less stability. A novel attempt has been made in present work to synthesize mannich base derivatives of alliin as stable analogs and screen for anti - infective activity. Method: Aliphatic, aromatic and heterocyclic aldehyde, Ketone, and amines were used for synthesis of mannich bases and were condensed with alliin to form mannich bases of alliin. Synthesized analogs were screened for in vitro bioactivity against gram positive Bacillus subtilis, gram negative Pseudomonas aeruginosa species and determination of zone of inhibition was done. Results: It is observed that all analogs have shown better activity than standard.1000?g/ml concentration solution of analogs was used for antimicrobial activity from results it is found that compound 3a shows maximum activity compared to standard drug. Conclusion: Mannich base derivatives of analogs containing all reactants having aliphatic nature have shown least activity. The analogs with aromatic structural feature have shown moderate to good activity, while analogs containing aromatic and heterocyclic structural features have shown highest anti - microbial activity. All synthesized analogs have shown better activity than standad which is in line with our clam that mannich base combined with alliin should show sinergestic activity.
Keywords: Anti infective, Mannich bases, Alliin, thiosemicarbazide, anti - microbial
Edition: Volume 12 Issue 6, June 2023,
Pages: 989 - 992