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Research Paper | Medicine | India | Volume 12 Issue 6, June 2023

Use of Mean Platelet Volume as a Predictor of Bleeding Risk in Thrombocytopenia

Dr. V. Parvathi | Dr. S. Narayanan Potti

Abstract: Introduction: A low platelet count is commonly encountered in clinical practice. Life threatening haemorrhages are a risk associated with severe thrombocytopenia, though it may not be seen in all such patients. Hence, there arises a need for determining the haemostatic potential in a thrombocytopenic patient. Rationale: Immature platelets have higher MPV and are found be more active. Hence the notion, higher MPV, lesser bleeding risk. Methods: This is a cross-sectional study conducted among 260 diagnosed cases of thrombocytopenia attending General Medicine department as OP and IP in Amala Institute of Medical Sciences, Thrissur from February 2021 to February 2022. Patients were monitored daily for bleeding manifestations and daily hemogram was done with Beckman Coulter counter and Sysmex counter. Data was analysed by using SPSS software, V.22. Results: Lower platelet counts were seen to be associated with higher MPV. Around 50% of the patients with bleeding manifestation had low mean platelet volume. Also, in around 96% of patients who did not have any bleeding manifestations, MPV was found to be on the higher side. Conclusions: Mean Platelet Volume can be used for predicting bleeding manifestations in patients with thrombocytopenia as patients with a lower MPV have higher risk of bleeding. Timing of platelet transfusions in thrombocytopenia has always been a matter of conflict as the prediction of bleeding was difficult. The mean platelet volume, which is obtained along with the hemogram in automated counters can be used as cheap method of predicting bleeding risk.

Keywords: Thrombocytopenia, bleeding, mean platelet volume

Edition: Volume 12 Issue 6, June 2023,

Pages: 593 - 597