International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Pharmacy | India | Volume 12 Issue 6, June 2023


Formulation Development and In Vitro Antacid Activity of Herbal Effervescent Granules

Goswami Priyanka | Ghodke Omkar | Chawda Jay


Abstract: The antacids act by neutralizing the acid in the stomach and by inhibiting pepsin, which is a proteolytic enzyme. Each of these cationic salts has a characteristic pharmacological property that determines its clinical use. In recent years, demands of identification and evaluation of new drugs possibly of plant origin are gaining popularity for the treatment of various gastrointestinal diseases. Hence, herbal medicines were considered a better substitute for the treatment of acid reflux/ acidity with lesser adverse side effects. The main objective of the study was to select herbs which were used as a home - remedy, having properties for neutralizing the acid of the stomach viz Cumin (Cuminumcyminum), Sprague (Trachyspermumammi), and Peppermint (Menthapiperita) and incorporate in their extract forms individually into the novel formulation (Effervescent granules) developed by using wet granulation method. Also, a formulation was developed by mixing extracts of Sprague and peppermint. The formulations developed were evaluated for flow properties, effervescence cessation time, and antacid properties. The antacid activity was determined using preliminary antacid test, acid neutralization potential, and acid neutralization capacity. The study proves the efficiency of the herbs used as an API in treating acidity. Along with the antacid activity, these herbs help to improve the secretion of enzymes and digestion in the gut.


Keywords: antacid, effervescent, acidity, Aurvedic, herbal


Edition: Volume 12 Issue 6, June 2023,


Pages: 496 - 499


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