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Research Paper | Medical Science | Volume 12 Issue 5, May 2023 | Pages: 2729 - 2736 | Egypt
Serum Albumin as a Prognostic Marker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Retrospective Study
Abstract: Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remain a major global cause of hospitalization, healthcare burden, and mortality. Methods: This single-center retrospective cohort study was conducted at Chest Department, Assiut University Hospitals, from July 2022 to March 2023 and aimed to evaluate whether admission serum albumin levels (g/dL) could predict in-hospital mortality among adults hospitalized with AECOPD and to assess their association with the need for noninvasive or invasive mechanical ventilation (NIV/IMV), intensive care unit (ICU) admission, and length of hospital stay (LOS). Results: Among 150 patients, hypoalbuminemia (<3.5 g/dL) was significantly associated with systemic inflammation, hypoxemia, prolonged hospitalization, and higher in-hospital mortality. Binary logistic regression identified low serum albumin as an independent predictor of mortality (OR = 0.041, 95% CI: 0.007-0.262, p = 0.001). Serum albumin and mGPS both demonstrated a good performance, with an AUC 0.82, and 0.725 respectively. Conclusion: These findings suggest that serum albumin and mGPS are reliable, low-cost prognostic biomarkers that may support early risk stratification in hospitalized patients with AECOPD.
Keywords: chronic obstructive pulmonary disease, hypoalbuminemia, hospitalization, mortality, prognostic biomarkers, mGPS, AECOPD
How to Cite?: Montaser Gamal Ahmed, Safaa Abdelgayed Eid, Mohamed Saad Abdelkader, "Serum Albumin as a Prognostic Marker in Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Retrospective Study", Volume 12 Issue 5, May 2023, International Journal of Science and Research (IJSR), Pages: 2729-2736, https://www.ijsr.net/getabstract.php?paperid=SR23531104422, DOI: https://dx.dx.doi.org/10.21275/SR23531104422