Design and Development of an Antifungal Microsphere based Topical Formula for Treating Skin Problems

Manjeet Kumar, Dr. Sanjay Kumar Kushwaha, Jyoti Vaish

Abstract: The main objective was to design diffusion controlled drug delivery system of antifungal drug in order to control or sustain the delivery of the drug and thereby reduce the gastrointestinal disturbances and dose related adverse effects like hepatic dysfunction and allergic reactions. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature and ideally having a particle size less than 200?m. This is the important approach in delivering therapeutic substance to the target site in sustained and controlled release. Microspheres were prepared by optimizing various parameters and studying their effects on particle size as well as entrapment efficiency. Size of microspheres affects the rate of drug release. As size decreases, the surface area - to - volume ratio of the particle increases. Microspheres was prepared with aim to deliver the drug which passes through transdermal route as it provides quick onset of action when compared to oral route.

Keywords: Microsphere, Transdermal delivery, Fungal infection, controlled release, Topical formulation