A Detailed View on COVID-19 and Coagulopathy

Dr Don J Scott Berin G, Prof. Dr. V J Beautlin Previncy

Abstract: Background: Corona Virus disease (COVID-19) rapidly spreading pandemic was initially found as a cluster of severe pneumonia cases in December 2019 reported in Wuhan, Hubei province, China. Infection with the virus, can be asymptomatic or mild to severe symptomatic disease causing Acute viral pneumonia like symptoms leading to fatality in the least possible time if untreated. The pathological cause of this is severe coagulopathies in the microvasculature primarily in the lungs causing hypoxia and later multiorgan failure. Though thrombolytics play an important role, it fail to recover the patient completely, and if so may have thrombolytic effects in other organs too which lead to complications. Objectives: The primary focus of this presentation article is on causation of coagulation mechanism in COVID-19 disease, resulting in multiorgan failure. Conclusion: The COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial Sepsis-Induced Coagulopathy (SIC) and disseminated intravascular coagulation (DIC). The CAC usually shows increased D-dimer and fibrinogen levels with minimal abnormalities in Prothrombin time and platelet count.

Keywords: Coagulation mechanism, COVID-19 coagulopathy