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Research Paper | General Surgery | India | Volume 12 Issue 6, June 2023
Correlation of Hormone Receptor Status with Prognostic Markers and Relapse Patterns in Breast Carcinoma
Dr. Dixit Methwani | Dr. J. L. Kumawat | Dr Ashish Jakhetiya | Dr. Rahul Rana [2]
Abstract: Background and objective: This retrospective study examines the correlation of hormone receptor status with prognostic factors such as age, menopausal status, tumour size, grade, histological type, lymph vascular invasion, and nodal metastasis in patients with biopsy proven breast cancer. The study involved 90 patients aged >18 years diagnosed with BIRADS 4. The results showed that hormone receptor expression is inversely correlated with tumour size and HER2neu over expression is associated with oestrogen and progesterone receptor positivity. Methods: 90 patients aged >18 years having Radiologically diagnosed with BIRADS 4 were planned for trucut biopsy in minor procedure room along which other than tissue diagnosis hormonal assessment was also sent immunohistochemistry. According to study selection criteria, patient information sheet, blood tests, imaging studies, postop recurrence was taken into account for study x. Results: The expression of hormone receptors is inversely correlated with tumour size, with smaller tumours expressing higher levels of receptor positivity. The statistical significance of this inverse association Lower HER-2/neu over expression was associated with oestrogen and progesterone receptor positive. Conclusion: The study concludes that hormone receptor status in breast carcinoma is inversely correlated with tumour size and HER2neu over expression. More postmenopausal women with tumours larger than 2 cm, Histological grade I, and nodal negative patients have oestrogen and progesterone receptor positive tumours. Oncoprotein over expression is frequent in patients with nodal positive tumours, grade III tumours, and tumours larger than 2 cm.
Keywords: Estrogen receptor, Progesterone receptor, HER 2/neu oncoprotein, Grading, Lymph node, Age
Edition: Volume 12 Issue 6, June 2023,
Pages: 127 - 130