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Review Papers | Dentistry | India | Volume 12 Issue 5, May 2023

Matrix Metalloproteinases (MMPs) As Diagnostic and Prognostic Tool - A Systematic Review

Dr. Suhani Goel

Abstract: Background: Periodontitis is a microbiological disease which is identified by the immune mediated degradation of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases resulting in degradation of extracellular matrix and basement membrane (BM) components. Method: Literature was searched systematically and studies were identified based on the-PICO (Glossary of evidence based terms 2007). A total of 10 studies were included in this systematic review. Result: This systematic review evaluated published RCTs on association of periodontal disease and levels of circulating MMPs along with the change in MMPs levels post periodontal therapy (NSPT). Conclusion: MMP levels decreases postoperatively in Gingival Crevicular Fluid (GCF) in Chronic Periodontitis patients.

Keywords: periodontitis, matrix metalloproteinases, immunity, inflammation, Gingival Crevicular Fluid

Edition: Volume 12 Issue 5, May 2023,

Pages: 1328 - 1331