Pharmacological Review of Diabetic Foot Ulcer-Inducing Methods and its Healing

Shalini B, Amudha P, Muralidharan P

Abstract: A metabolic illness called diabetes mellitus is characterized by numerous long-term consequences impacting practically all bodily systems. One of the most common side effects of diabetes is foot ulcers. The exact pathophysiology of a diabetic foot ulcer is clearly unknown and it may be induced due to various factors. Impaired diabetic wound repair is mainly caused by diabetic neuropathy, peripheral vascular disease, and aberrant cellular, and cytokine / chemokine activity. Treatment for DFU is based on the severity of the ulcer which is assessed by the Wagner ulcer classification system. Furthermore, the most preferred treatment for foot ulcersis antibiotic therapy, revascularization, debridement, off-loading, and amputation. This review also discusses screening methods for diabetic foot ulcers in rats such as in vitro and invivo models.

Keywords: Diabetic foot ulcer, Wound healing, Diabetes Mellitus, Foot care