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Research Paper | Surgery | India | Volume 12 Issue 4, April 2023
Comparative Study of Efficacy of Ondansetron versus Ondansetron and Dexamethasone Combination in Preventing Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy
Dr. Aparajita Singh [5] | Dr. Ramendranath Talukdar [3] | Dr. P. N. Agarwal | Dr. K. S. Goel [2] | Dr. Vishwendra Singh
Abstract: This study aimsto compare the efficacy of Ondansetron alone versus Combination of Ondansetron and Dexamethasone in terms of preventing Postoperative Nausea and Vomiting, Pain and duration of hospital stay. Material and Methods: A prospective interventional randomized control study was conducted in the Department of General Surgery, SGT Medical College Hospital and Research Institute, Gurgaon, Haryana. The randomization was done according to the standard methods to allocate the patients to either Group A (total 30 patients) receiving Ondansetron 4mg + 2ml normal saline (total of 3ml) intravenous (IV), 1 minute before induction of anesthesia and Group B (total 30 patients) receiving Ondansetron 4mg and Dexamethasone 8mg (total of 3ml) IV, 1 minute before induction of anesthesia. Adequate sample size of 60 patient fulfilling inclusion and exclusion criteria mentioned are studied. The data was collected in a pre - designed study proforma and statistical analysis was performed. The treatment and drug efficacy were compared between two groups in terms of postoperative nausea and vomiting, pain and duration of hospital stay. Result: The total incidence of post - op nausea and vomiting following administration of Dexamethasone along with ondansetron was 1 patient (3.3 %) whereas 15 patients (50%) in group where dexamethasone was not administered which is significant. The 1 patient of Group B was a case of abdominal tuberculosis with fibrosis of stomach serosa. Marked relief in post - op pain and shorter hospital stay was observed in group B which was administered steroid. Conclusion: From this study, we can conclude that administration of steroid like dexamethasone along with Ondansetron has significant role in prevention of post - op nausea and vomiting, pain and gives shorter hospital stay, making it a necessary step to be followed when performing Day - care Laparoscopic Cholecystectomy.
Keywords: laparoscopic cholecystectomy, post - operative nausea, PONV, dexamethasone, ondansetron
Edition: Volume 12 Issue 4, April 2023,
Pages: 842 - 843