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Research Paper | Pharmaceutical Science | India | Volume 12 Issue 3, March 2023
Evaluation of Antioxidant and Hypolipidaemic Potential of Elaeocarpus Ganitrus
Shubham Pandey [2] | Kratika Daniel | Neelam Jain [3]
Abstract: Objective: The present study was aimed to evaluate the leavesof Elaeocarpus ganitrus for its antioxidant and hypolipidaemicpotential. Methods: E. ganitrus leaf powder was extracted in ethanol and the crude extract was divided into aqueous ethyl acetate, butanol, methanol and 70: 30 (ethanol: water) mixture yielded pure compounds like gallic acid, quercetin and ellagic acid. Ethanolic extracts of leaves were subjected to phytochemical screening to determine the presence of alkaloids, steroids, saponins, glycosides and flavonoids. Free radical scavenging techniques (DPPH and ABTS) and the ferric reducing antioxidant power (FRAP) were used to measure the antioxidant activity. Diet - induced hyperlipidemic model and triton - induced hyperlipidaemic model was used to measure the hypolipidaemicpotential. Results: Based on the findings, it was concluded that E. ganitrus is a very plant in several components such as flavonoids, triterpenes, quercetin and carbohydrates. The active fraction of E. ganitrus leaves showed potent antioxidant activity against DPPH free radical. Triton - induced hyperlipidemic control rats had significantly higher serum lipid and lipoprotein levels. Simultaneously, a rise in HDL - cholesterol was noted. When compared to hyperlipidemic controls, E. ganitrus leaves chloroform extract significantly lowered blood lipids (p<0.001). Conclusion: Thus, the leaves of E. ganitrus may be considered as a promising plant extract for the control of oxidation and hyperlipidaemia.
Keywords: E. ganitrus leaves; Hypolipidemia; Anti - oxidant; Cholesterol; DPPH
Edition: Volume 12 Issue 3, March 2023,
Pages: 821 - 825