International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 2, February 2023 | Rating: 5.4 / 10


To Compare Effect of Intrathecal Dexmedetomidine versus Clonidine as an Adjuvant to 0.5% Hyperbaric Bupivacaine in Orthopaedic Lower Limb Surgeries under Spinal Anaesthesia - A Prospective Double Blind Randomised Control Study

Ritushree Sharma [3] | Pratheev E [3] | Arpita Bhargava [3] | Rajan Nanda [6]


Abstract: Background: The aim of this study was to compare the effects of dexmedetomidine and clonidine used as adjuvants to 0.5 % hyperbaric bupivacaine in lower limb orthopaedic surgeries under spinal anaesthesia. Material and Methods: The prospective clinical study ? Randomized controlled trail was conducted in ninety patients of any gender divided in three groups. In Group - C, Group - D, Group - N (n=30 each) patients received 50mcg of Clonidine (0.5ml), 5mcg of dexmedetomidine and 0.5ml normal saline along with 12.5mg of hyperbaric bupivacaine respectively for spinal anaesthesia. These groups were compared using one - way analysis of variance (ONE - WAY ANOVA) and difference between the groups compared using unpaired T - test. Results: Duration of analgesia was more with intrathecal dexmedetomidine. Conclusion: We concluded that the supplementation of bupivacaine with dexmedetomidine 5?g or clonidine 50?g in spinal anaesthesia produces significantly shorter onset of motor and sensory block with longer duration of sensory and motor block when compared to bupivacaine alone. Amongst dexmedetomidine and clonidine, dexmedetomidine shows significantly longer duration of analgesia than clonidine which proves it to be better adjuvant than clonidine at the mentioned dose.


Keywords: Clonidine, Dexmedetomidine, Bupivacaine


Edition: Volume 12 Issue 2, February 2023,


Pages: 1477 - 1484


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