International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 2, February 2023 | Rating: 5.3 / 10


Comparative Study of Oral Pregabalin Vs Gabapentin for Post Operative Analgesia in Lower Limb Surgeries under Spinal Anaesthesia

Sukriti Bhardwaj [2] | S. P. Chittora [8] | Aksha Khan


Abstract: Background and aim: Pre - emptive analgesia is an anti ? nociceptive treatment that prevents establishment of altered processing of afferent input which amplifies post operative pain. The aim of the study is to evaluate and compare the pre - emptive analgesic efficacy of oral pregabalin vs oral gabapentin for postoperative analgesia in patients undergoing elective orthopaedic lower limb surgeries under spinal anaesthesia. Methodology: This study included 90 patients, who were divided into 3 groups of 30 each. Group P received Tablet pregabalin 300 mg, Group G received Tablet gabapentin 900 mg and Group C received placebo tablets (multi vitamin) preoperatively 2 hrs before surgery. Parameters like duration of analgesia, visual analogue score (VAS), Ramsay sedation score were recorded. Result: The mean duration of analgesia was 535.6, 305.03 and 156.53 minutes in Group P, Group G and Group C respectively. These differences were statistically significant. Conclusion: This study shows that Pre - emptive Pregabalin and Gabapentin provides good post operative analgesia compared to placebo and Pregabalin (300mg) provides prolonged pain relief compared to Gabapentin (900mg) in the post operative period. Pregabalin and Gabapentin reduce post operative opioid requirement in the first 24 hours post - surgery with very less adverse events.


Keywords: Pregabalin, Gabapentin, Pre - emptive analgesia


Edition: Volume 12 Issue 2, February 2023,


Pages: 1419 - 1426


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