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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 2, February 2023
A Randomized Double - Blind Study to Compare the Effect of 0.5% Bupivacaine with Buprenorphine and 0.5% Bupivacaine with Fentanyl in Lower Limb Surgeries under Epidural Anaesthesia
Arpita Bhargava [3] | Pratheev E [3] | Ritushree Sharma [3] | Rajan Nanda [6]
Abstract: Background: For lower abdominal and lower limb surgeries, regional anaesthesia is preferred over General anaesthesia. Epidural anaesthesia is useful as a primary anaesthetic, but most commonly, it is used as a pain management adjuvant. We evaluated compare the effect of 0.5% bupivacaine with buprenorphine and 0.5% bupivacaine with fentanyl in lower limb surgeries under epidural anaesthesia. Material and methods: A randomized double blind study was conducted in 90 patients of either gender divided in three groups. In Group A (n=30) patients were received 0.5% bupivacaine 15 ml with 0.5 ml Buprenorphine with 0.5 ml and normal saline made to a total 16 ml. in Group B (n=30) patients were received 0.5% bupivacaine 15 ml with 1 ml fentanyl and in Group C (n=30) patients were received 0.5% bupivacaine 15 ml with 1 ml normal saline for epidural anaesthesia. These groups were compared using one - way analysis of variance (ONE ?WAY ANOVA) and difference between the groups compared using unpaired T - Test. Results: Duration for analgesia was more with epidural Buprenorphine. Conclusion: We concluded that epidural Buprenorphine is better in providing prolonged satisfactory postoperative analgesia as compared to Fentanyl.
Keywords: Isobaric Bupivacaine, Buprenorphine, Fentanyl, Epidural
Edition: Volume 12 Issue 2, February 2023,
Pages: 1372 - 1377