Oxcarbazepine - Induced Symptomatic Hyponatremia - A Case Report

Vaddiparthi Navya, Kode Akhil Yadav

Abstract: Oxcarbazepine, a newer anti - epileptic drug, is a structural analogue of carbamazepine and is used to treat partial seizures. Though it is thought to be safer with relatively milder side effects than Carbamazepine, serious adverse events have been occasionally noted. One of those is oxcarbazepine - induced hyponatremia due to its direct action on renal tubules. The risk is especially high in elderly patients and those receiving anti - epileptic drug polytherapy and diuretics. Oxcarbazepine - induced hyponatremia is usually mild and responds to fluid restriction alone, but at times it may become severe enough to cause hospitalisation. Our case is a 68 - year - old gentleman with Parkinson disease and partial seizures on oxcarbazepine who presented with generalised tonic - clonic seizures and altered sensorium secondary to drug - induced hyponatremia.

Keywords: Oxcarbazepine, Anti - epileptic drug, Hyponatremia, Seizures, Altered sensorium