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Research Paper | Emergency Medicine | India | Volume 12 Issue 2, February 2023
Utility of Serum Neurofilament Light Protein as a Biomarker in Traumatic Brain Injury
Shalini Pasupuleti | Satish Kumar Putta | Vamsi Krishna Yerramneni | Ashima Sharma [2]
Abstract: Objective: Traumatic Brain Injury (TBI) is the most predominant cause of morbidity globally. The load of TBI in all age groups leads to a raise in the cost of treatment. The addition of blood biomarkers can provide more reliable information about neuronal injury and can aid clinical evaluation without sacrificing sensitivity. They may also serve as cost - effective tools with good specificity of TBI. Methodology: 34 severe TBI patients between 2019 to 2020, admitted to Nizam?s Institute of Medical Sciences, Hyderabad, India were enrolled.30 orthotrauma patients (OT) and 30 Healthy controls were also included in the study. All the participants were assessed for serum levels of Neurofilament Light protein (NFL) and S100B. Results: Serum NFL and S100B concentrations of the severe TBI patients on day 0 ranged from 150.8 to 414.6 pg/ml and 705.26 to 3747.37 pg/L. The NFL was markedly higher in severe TBI patients than Healthy controls and OT patients. The values at d0 after injury of NF - L (p=0.012) and S100B (p=0.202) and over the hospital stay were significantly higher in non survivors vs. survivors. Conclusion: NFL would help for better prognostication in TBI patients. Measurement of NFL in serum may be useful to assess the axonal degeneration by knowing the severity of TBI especially in long term impairment, Whereas, S100b can be useful to diagnose the disease.
Keywords: Traumatic brain injury, Neurofilament light protein, s100b, axonal injury, orthotrauma patients
Edition: Volume 12 Issue 2, February 2023,
Pages: 468 - 473