Effect of the Nutritional Supplement Synertox on Lead - Induced Toxicity in Male Albino Rats

Mohammed Al - Zhrani, Mohammed Mubarak, Hassan Ahmed Rudayni, Mohammed Al - eissa

Abstract: Background: Synertox is a supplement of high nutritional value containing a cocktail of highly rich ingredients. Lead is one of the well-known hazardous heavy metals. The current study was conducted to investigate the probable role of synertox to ameliorate the lead-induced toxic effects. Materials and Methods: For this purpose, 60 male albino rats were randomly divided into 3 groups, of 20 animals each, designated groups 1, 2 and 3. Rats in group 1 served as untreated control, group 2 animals were intoxicated by lead and group 3 rats were exposed to lead and received synertox in their drinking water. Results: All hematological and biochemical parameters were altered in the lead intoxicated rats (group 2) compared to control group. Addition of synertoxin group 3 resulted in increasing the erythrocytic indices, including RBCs count, hemoglobin concentration and hematocrit %. Biochemical parameters of group 3 disclosed comparatively increased levels of total proteins and decreased levels of creatinine, urea, bilirubin and serum enzymes in relation to the levels recorded in group 2 (lead intoxicated animals). Conclusion: It was concluded that synertox as a highly concentrated nutritional supplement may provide an ameliorating effect on the lead induced toxicity as judged by the encountered hematological and biochemical profiles.

Keywords: Lead toxicity, synertox, antioxidant, hematological changes, biochemical Profile