Downloads: 2 | Views: 121 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies | Obstetrics and Gynecology | India | Volume 12 Issue 1, January 2023

Spontaneous Conception Following Ulipristal Acetate on Treating Uterine Fibroid - A Case Report

Dr. Ramya Selvaraj | Dr. Shanthi

Abstract: A case report of a clinical pregnancy after use of ulipristal acetate (UA) to decrease uterine fibroid size. A 35yrs old women, PARA 1, LIVE 1, ABORTION 1, presented with findings of fibroid uterus for which laparotomy myomectomy was done. Following surgery (8 months post surgery) ULIPRISTAL ACETATE 5mg for 13 weeks daily was given as a further management. We measured the shrinkage of fibroids and the morphology of the endometrial cavity in order to study the possibility of pregnancy following treatment. An ultrasound of the endometrium after treatment showed that uterine fibroids had decreased and the morphology of the endometrium had become normal. During the endometrial biopsy, no histological endometrial changes were observed. The patient presented in OPD with amenorrhea for 6 weeks after completing the ulipristal acetate treatment and pregnancy was confirmed by ultrasound four months after end of treatment. After treatment patient underwent an successful pregnancy. After prior myomectomy, a spontaneous pregnancy (by use of UA) which was used in decreasing the size of fibroid which may suggest a potential medical benefit of this selective progesterone receptor modulator in the management of women who desire pregnancy but have uterine fibroids after surgery. The use of UA may be beneficial for patients who do not agree for surgical procedure and/or those planning to undergo Assisted Reproductive Technique (ART). After the treatment is complete, one can immediately try to conceive and avoid the risks of further surgery.

Keywords: Fibroid uterus, Ulipristal acetate, Spontaneous pregnancy, Myomectomy, Endometrium

Edition: Volume 12 Issue 1, January 2023,

Pages: 1103 - 1105