Implications of Tobacco Smoke on the Lung Histopathology of Albino Rats in Relation to Sex

Nibha Rathore, B. S. Sharma

Abstract: The purpose of this study was to explore the histopathological changes in lungs of both sexes of albino rats. Experimental rats (150-200 gram) were kept in standard laboratory conditions and grouped into 6 sets (5 rats each)-Control rats (IM and IF) without exposure, For 60 days, six filtered cigarettes were exposed to the fumes of cigarettes hourly on the experimental rats (IIM and IIF). For a period of 120 days, six filtered cigarettes were exposed to the smoke of experimental rats (IIIM and IIIF). When comparing the lung tissue of rats exposed to tobacco smoke to that of control rats, several histopathological alterations were noted, including pulmonary edema, debris, thick epithelium, and capillary permeability. Given that female rats are more sensitive than male rats, these changes are more noticeable in female rats after 120 days of tobacco smoke inhalation.

Keywords: Tobacco smoke, Albino rats, Lung Histopathology