Synthesis and Bioevaluation of Novel Thiazolidinones from Aromatic Azo-Aldehydes

Shivani D. Kawale, Dr. Gayatri Phadnaik

Abstract: Some novel substituted 4-Thiazolidinones (azo-dispersive dyes) were synthesized from azo-incorporated aromatic aldehydes (1a-1c) and heteryl hydrazides (2a-2b) in zinc chloride and DMF via synthesis of azomethines (Schiff bases) (4a-4e) conventionally by using mercaptoacetic acid, a very important precursor responsible for cyclization of azomethines.

Keywords: 4-Thiazolidinones, azo-incorporated aromatic aldehydes, heteryl hydrazides, azomethines, mercaptoacetic acid