International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




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Research Paper | Medicine | India | Volume 12 Issue 12, December 2023 | Rating: 4.4 / 10


Mixed Connective Tissue Disease - A Tertiary Centre Experience

Divya Y [2] | Rajeswari S [2] | Balaji C [4] | Saranya C [3] | Grishma D [2] | Akanksha S [11] | Vishwa Prakash T [2] | Nidhi R P | Lakshmi Tejaswi K [2]


Abstract: The diagnosis of MCTD is based on specific criteria. There are few Studies on MCTD available in Indian population. This study aims to describe the clinical profile, immunological profile and outcome in patients with MCTD. This is a retrospective observational study, data taken from hospital records over 4 years (2017-21) done at SRIHER. Patients were diagnosed as MCTD by Alarcon - Segovia criteria. The clinical data, immunological profile, treatment given and outcome on follow up were noted. On follow up, the disease predominant manifestations of MCTD were observed. Autoantibody profile using Line immune assay 15 was noted. CYC was given for 17 patients, MMF for 11 patients, RTX for 5 patients, MTX for 9 patients, AZA for 1. Patients were followed up for mean duration of 2.2 years. 2 patients died due to sepsis. Strong female preponderance was observed in our cohort. Musculoskeletal involvement was the most common manifestation. Systemic sclerosis predominant features were common.


Keywords: Mixed connective tissue disease, Interstitial lung disease, Raynauds, Pulmonary artery hypertension, myositis


Edition: Volume 12 Issue 12, December 2023,


Pages: 1706 - 1709



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