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Comparative Studies | Medicine Science | India | Volume 12 Issue 12, December 2023
Comparative Efficacy of Targeted Therapies in Treating Multiple Domains of Psoriatic Arthritis - A Single Center Study
Grishma D [2] | Rajeswari S [2] | Saranya C [3] | Balaji C [4] | Aishwarya R [5] | Divya Y [2] | Vishwa Prakash T [2] | Akanksha S [11] | Lakshmi Tejaswi K [2] | Nidhi P [9]
Abstract: Targeted therapies are commonly used in the management of Psoriatic arthritis (PsA). The Objective of our study is to investigate the comparative efficacy and safety of adalimumab (A), secukinumab(S) and tofacitinib(T) for patients with active PsA.A 3-year single centre study was conducted among PsA patients treated with either A/S/T. Primary objective was major clinical improvement (ACR50 and ASAS40) at week 24 and improvement in other domains (enthesitis, dactylitis and skin) were studied as secondary objectives. Disease activity scores (PASDAS, PASI, BASDAI) were computed. 79 patients with a were included. Adalimumab may be preferable for treating arthritis. Secukinumab shows significantly better response in treating axial symptoms, enthesitis and dactylitis. High CRP (>10.8), smoking and baseline BASDAI were predictors of clinical response.
Keywords: Psoriatic arthritis, Adalimumab, secukinumab, Tofacitinib
Edition: Volume 12 Issue 12, December 2023,
Pages: 339 - 344