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Research Paper | Public Health Education | India | Volume 12 Issue 2, February 2023

In - Vitro Evaluation of Antihelmenthic Activity of Extracts of Ocimum Gratissimum and Coriandrum Sativuml

K. Naga Kumari | Bathula Harika | Nimmagadda Tejeswar Prasad | Nakka Suryakantha | Polavarapu Vipunika Kanthi | Saridena Mary Rose | Thota Bhargavi Yaram Ashok Reddy

Abstract: The present study investigated anthelmintic resistance and the high cost of conventional anthelmintic drugs it leads to the evaluation of medicinal plants as an alternative source of anthelmintics. The anthelmintic activity of ethanolic leaf extracts of Coriandrum sativum and ocimum gratinissimum. In - vitro experiments were conducted to determine the possible anthelmintic effects. Data in the table 1 reveals that the extracts of ocimum gratinissimum plant took the less time to cause paralysis of the earthworm than that of coriandrum sativum extract. The three concentrations of Coriandrum sativum and ocimum gratinissimum (50, 100, and 150 mg/ml) showed paralysis at 87.00, 42.33 and 32.33 min and death at 191.66, 146.00 and 88.33 min and (50, 100, and 150 mg/ml) paralysis at 97.33, 72.00 and 48.66 min and death at 215.00, 152.00 and 109.66 min of the worms. The standard drug, Piperazine citrate showed paralysis at 21.66 min and death after 72.33 min at 15mg/ml concentration and control was used as water. From the above result, it is clear that extracts of ocimum gratinissimum and Coriandrum sativum plants have significant anthelmintic activity in dose dependent manner when compared with standard anthelmintic drug. It can be concluded that the active constituents responsible for anthelmintic activity present in the both extracts of Coriandrum sativum and ocimum gratinissimum plants.

Keywords: Anthelmintic activity, Coriandrum sativum and ocimum gratinissimu plants, Pheritima posthuma, Ascardia galli, Piperazine citrate.

Edition: Volume 12 Issue 2, February 2023,

Pages: 139 - 143