Synthesis and Characterization of Sugar Derived Novel Bioactive Isoxazole Derivatives

Amrendra Kumar Singh ^[2] | Ram Naresh Yadav | Vijay Pratap Singh ^[4]

Abstract: This study explores the synthesis and characterization of novel isoxazole derivatives derived from sugar. We employed 1-3 dipolar cycloaddition between aldoxime dipole precursor and alkyne derivative of sugar dipolarophile in presence of weak base at 00C in DMF. The newly synthesized isoxazole derivatives as cycloadducts were separated from solvent and characterized by IR, 1H NMR, and 13C NMR.

Keywords: Isoxazole, Nitrile oxide, 1-3 dipolar cycloaddition, Hetero-cyclization reaction, dipolarophile

Edition: Volume 12 Issue 11, November 2023,

Pages: 1610 - 1613

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Synthesis and Characterization of Sugar Derived Novel Bioactive Isoxazole Derivatives

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