Synthesis of Antimicrobial, Amino Pyrano [2, 3-c] Pyrazolone Carbonitrile Derivatives by Thiourea Catalyzed Hetero-Cyclization Reaction
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Chemistry | India | Volume 12 Issue 11, November 2023 | Popularity: 4.7 / 10


     

Synthesis of Antimicrobial, Amino Pyrano [2, 3-c] Pyrazolone Carbonitrile Derivatives by Thiourea Catalyzed Hetero-Cyclization Reaction

Vijay Pratap Singh, Amrendra Kumar Singh


Abstract: Hetero Diels-Alder reaction for direct [4+2] cycloaddition between vinyl pyrazolone and conjugate amino alkene carbonitrile, catalyzed by thiourea derivatives in DMSO at room temperature gives pyrano[2, 3-c] pyrazolone derivatives. The newly synthesized compounds show antimicrobial activity against Gram positive bacteria (S. aureus and B. subtilis), Gram negative bacteria (P. aeruginosa and E. coli) and antifungal activity against fungi (A. niger).


Keywords: Pyrano [2, 3-c] pyrazole, thiourea derivatives, Hetero cycloaddition reaction, Antimicrobial agent


Edition: Volume 12 Issue 11, November 2023


Pages: 1313 - 1317


DOI: https://www.doi.org/10.21275/SR231117233234



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Vijay Pratap Singh, Amrendra Kumar Singh, "Synthesis of Antimicrobial, Amino Pyrano [2, 3-c] Pyrazolone Carbonitrile Derivatives by Thiourea Catalyzed Hetero-Cyclization Reaction", International Journal of Science and Research (IJSR), Volume 12 Issue 11, November 2023, pp. 1313-1317, https://www.ijsr.net/getabstract.php?paperid=SR231117233234, DOI: https://www.doi.org/10.21275/SR231117233234

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