Synthesis of Antimicrobial, Amino Pyrano [2, 3-c] Pyrazolone Carbonitrile Derivatives by Thiourea Catalyzed Hetero-Cyclization Reaction

Vijay Pratap Singh, Amrendra Kumar Singh

Abstract: Hetero Diels-Alder reaction for direct [4+2] cycloaddition between vinyl pyrazolone and conjugate amino alkene carbonitrile, catalyzed by thiourea derivatives in DMSO at room temperature gives pyrano[2, 3-c] pyrazolone derivatives. The newly synthesized compounds show antimicrobial activity against Gram positive bacteria (S. aureus and B. subtilis), Gram negative bacteria (P. aeruginosa and E. coli) and antifungal activity against fungi (A. niger).

Keywords: Pyrano [2, 3-c] pyrazole, thiourea derivatives, Hetero cycloaddition reaction, Antimicrobial agent

How to Cite?: Vijay Pratap Singh, Amrendra Kumar Singh, "Synthesis of Antimicrobial, Amino Pyrano [2, 3-c] Pyrazolone Carbonitrile Derivatives by Thiourea Catalyzed Hetero-Cyclization Reaction", Volume 12 Issue 11, November 2023, International Journal of Science and Research (IJSR), Pages: 1313-1317, https://www.ijsr.net/getabstract.php?paperid=SR231117233234, DOI: https://dx.doi.org/10.21275/SR231117233234