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Review Papers | Biological Sciences | Bulgaria | Volume 12 Issue 1, January 2023
Biological Effects of Secondary Plant Metabolites on the Expression of Key Factors Involved in DNA Damage Response Signaling Pathway and Apoptosis in Cancer Cell Lines
Neli Dimitrova | Borislav Popov
Abstract: Various types of external events, as well as internal processes in the cell continuously create conditions for DNA damage. For protection, cells developed DNA damage response network (DDR), representing a cascade of linked cellular and molecular events to eliminate critical and dangerous conditionsin order to maintain genome stability. Disturbances in DDR are a causative factor in the occurrence of cancer. Study in proteins involved in DDR can be used for therapeutic purposes for detecting, predicting and treating cancer [1]. Plant extracts, and in particular, the secondary metabolites in which they are rich, show great modulatory effects of major components of DDR. In this review, we aim to show the molecular mechanism of action of some secondary metabolites studied in recent years on the DDR network, and summarize whether common principles of their action can be found.
Keywords: bioactive compounds, cell death, DDR, oxidative stress, plants
Edition: Volume 12 Issue 1, January 2023,
Pages: 533 - 541