An Emergent Synthesis of Novel Isoxazolidines Via 1,3-Dipolar Cycloaddition of ?-Cinnamic Aryl-N-Aryl Nitrone with ?-Nitrostyrene and IT?S Antibacterial Activities

M. R. Bhamuni, S. R. Jayapradha

Abstract: A new series of isoxazolidine derivatives are synthesized with good yields by 1,3-dipolar cycloaddition reaction between newly synthesized nitrones and an efficient dipolarophile ?-nitrostyrene. The ?-Cinnamic aryl-N-aryl nitrone and ?-nitrostyrene as a novel class of dipolarophile has been synthesized in shortened reaction time to get an excellent yield. This specific nitrone and dipolarophiles are refluxed in the presence of toluene in a conventional method to give a five membered heterocyclic compound namely isoxazolidine. The structure of all the synthesized isoxazolidines are characterized by FT-IR, Uv-vis spectroscopy, 1H and 13C NMR spectra. The cycloadducts-isoxazolidines formed also exhibit a biological activities.

Keywords: Isoxazolidine, 1,3-dipolar cycloaddition, Cinnamaldehyde, Nitrone, Dipolarophile