International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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India | Chemistry | Volume 12 Issue 11, November 2023 | Pages: 700 - 707


An Emergent Synthesis of Novel Isoxazolidines Via 1,3-Dipolar Cycloaddition of ?-Cinnamic Aryl-N-Aryl Nitrone with ?-Nitrostyrene and IT?S Antibacterial Activities

M. R. Bhamuni, S. R. Jayapradha

Abstract: A new series of isoxazolidine derivatives are synthesized with good yields by 1,3-dipolar cycloaddition reaction between newly synthesized nitrones and an efficient dipolarophile ?-nitrostyrene. The ?-Cinnamic aryl-N-aryl nitrone and ?-nitrostyrene as a novel class of dipolarophile has been synthesized in shortened reaction time to get an excellent yield. This specific nitrone and dipolarophiles are refluxed in the presence of toluene in a conventional method to give a five membered heterocyclic compound namely isoxazolidine. The structure of all the synthesized isoxazolidines are characterized by FT-IR, Uv-vis spectroscopy, 1H and 13C NMR spectra. The cycloadducts-isoxazolidines formed also exhibit a biological activities.

Keywords: Isoxazolidine, 1,3-dipolar cycloaddition, Cinnamaldehyde, Nitrone, Dipolarophile

How to Cite?: M. R. Bhamuni, S. R. Jayapradha, "An Emergent Synthesis of Novel Isoxazolidines Via 1,3-Dipolar Cycloaddition of ?-Cinnamic Aryl-N-Aryl Nitrone with ?-Nitrostyrene and IT?S Antibacterial Activities", Volume 12 Issue 11, November 2023, International Journal of Science and Research (IJSR), Pages: 700-707, https://www.ijsr.net/getabstract.php?paperid=SR231108183720, DOI: https://dx.doi.org/10.21275/SR231108183720


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