Melatonin, Catecholamines, and Histamine in Immunopathology: Unraveling the Neurobiological Mechanisms of Inflammation and Cancer

G. Dundua, A. Tavartkiladze, G. Simonia, P. Revazishvili, R. Khutsishvili, I. Andronikashvili, D. Egiazarovi

Abstract: Immunopathological conditions characterized by dysregulated immune responses and chronic inflammation pose significant challenges in healthcare. Understanding the intricate interplay between the neurochemicals melatonin, catecholamines (dopamine and noradrenaline), and histamine, and their impact on immune function and inflammation, is crucial for developing targeted therapies. Moreover, their involvement in cancer progression further emphasizes the need to unravel the underlying neurobiological mechanisms. This comprehensive research project aims to investigate the immunomodulatory roles of melatonin, catecholamines, and histamine in inflammation and cancer, with the ultimate goal of identifying potential therapeutic targets and diagnostic markers.

Keywords: Immunopathology, inflammation, cancer, melatonin, catecholamines, dopamine, noradrenaline, histamine, immune response, neuroimmune axis, therapeutic targets