From Genes to Disease: A Comprehensive Review of Host Genetic Determinants in Infectious Susceptibility

M. Sadhika Reddy, V. R Hithesh Sri Sai Reddy, C. Prabhakar Raju

Abstract: In the intricate landscape of infectious diseases, understanding why certain individuals succumb while others resist is of paramount importance. While environmental and pathogenic factors undoubtedly play crucial roles, the genetic makeup of the host stands as a cornerstone in this equation. "From Genes to Disease" provides an exhaustive review of the genetic underpinnings influencing an individual's susceptibility to infectious agents. Drawing upon current research, this review unravels the complex web of single-nucleotide polymorphisms, gene clusters, and epigenetic modifications that dictate host-pathogen interactions. The role of human leukocyte antigen (HLA) genes, innate immunity regulators, and other genetic factors are discussed in-depth, offering insights into their impact on infectious disease dynamics. Additionally, the paper explores the potential of personalized medicine in tailoring therapeutic and preventive strategies based on an individual's genetic profile. Through the synthesis of current knowledge, this review underscores the profound implications of host genetics on infectious disease susceptibility, providing a roadmap for future research in the realm of genetic epidemiology and personalized medicine.

Keywords: Genetics, Infectious Diseases, Susceptibility, Host Genetics, Genetic Determinants

How to Cite?: M. Sadhika Reddy, V. R Hithesh Sri Sai Reddy, C. Prabhakar Raju, "From Genes to Disease: A Comprehensive Review of Host Genetic Determinants in Infectious Susceptibility", Volume 12 Issue 10, October 2023, International Journal of Science and Research (IJSR), Pages: 2096-2098, https://www.ijsr.net/getabstract.php?paperid=SR231028102003, DOI: https://dx.doi.org/10.21275/SR231028102003