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Research Paper | Chemical Sciences | India | Volume 12 Issue 11, November 2023
Association between Organophosphate Pesticide Exposure and Type-2 Diabetes
Asiya Khatoon Zainuddin | Mamta Gour Patel [2]
Abstract: This study delves into the intricate relationship between the incidence of type 2 diabetes and exposure to organophosphate (OP) insecticides, shedding light on a matter of growing concern for public health. Employing a systematic approach, the research encompasses two distinct phases, with the primary objective of unraveling the potential link between OP pesticide exposure and the prevalence of diabetes. A comprehensive review of existing literature underscores the urgency of this investigation. Recent studies have consistently hinted at a positive association between pesticide exposure, particularly OP pesticides, and the elevated risk of developing type 2 diabetes. Mechanistic research has provided valuable insights into the biological plausibility of this link, demonstrating how pesticides can disrupt insulin signaling and glucose metabolism. Phase 1 of the study, a cross-sectional examination, reveals a significantly higher prevalence of type 2 diabetes among individuals with documented OP pesticide exposure compared to a control group without such exposure. This finding emphasizes the relevance of further exploration. Phase 2 focuses on a cohort of OP pesticide applicators, offering a deeper understanding of the exposure-response relationship. The results illustrate a clear dose-response pattern, with higher pesticide exposure correlating with an increased incidence of type 2 diabetes among pesticide applicators. These findings underscore the need for enhanced safety precautions and awareness campaigns among pesticide users. Moreover, they advocate for regulatory measures to minimize human exposure to OP pesticides. While acknowledging the study's limitations, including potential confounders, the results emphasize the imperative of continued research and prompt action to mitigate the potential health risks associated with pesticide usage. This study not only advances our comprehension of the pesticide-diabetes nexus but also underscores the urgency of safeguarding the health of individuals and communities exposed to pesticides.
Keywords: Organophosphate pesticides, Type 2 diabetes, Pesticide exposure, Epidemiological study, Health implications
Edition: Volume 12 Issue 11, November 2023,
Pages: 50 - 53