Pharmacological and Biological Activities of Azetidinone models: A Brief Overview

Punith Kumar

Abstract: Azetidinones represent a four-membered heterocyclic ring system with nitrogen as the heteroatom and a carbonyl group integrated within its structure. These compounds are also commonly referred to as ?-lactams. Their broad-spectrum antibacterial activity encompasses both gram-positive and gram-negative bacteria. Beyond their antibacterial properties, this review also explores the antimicrobial, anti-tubercular, anti-convulsant, anti-cancer, anti-depressant, anti-inflammatory, and central nervous system (CNS) activity of azetidinones. The various pharmacological traits connected to the monocyclic 2-azetidinone moiety are the main focus of this review. The most current and pertinent references have been covered with care.

Keywords: Azetidinones, Biological activity, Anti-bacterial