Downloads: 6 | Views: 80 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Review Papers | Microbiology | India | Volume 12 Issue 10, October 2023

Exploring Methioninase-Producing Fungi: Screening, Characterization, and Pharmaceutical Implications

Apurva Munje | Dr. Umesh Kumar Dhurwe | Dr. Sunil Kumar Snehi ^[2]

Abstract: Methioninase, an enzymatic powerhouse with profound pharmaceutical potential, has emerged as a compelling candidate for innovative therapeutic interventions. This review embarks on an exploration of Methioninase-producing fungi, with a specific focus on the screening, characterization, and pharmaceutical implications of these fungal strains. Drawing upon a wealth of scientific literature, we delve into the multifaceted facets of Methioninase research, aiming to elucidate its pivotal role in addressing diverse medical conditions. Methioninase, known for its enzymatic prowess in metabolizing methionine, offers promising avenues for medical applications. Its potential therapeutic benefits span a spectrum of ailments, including cancer and liver diseases, rendering it a subject of intense scientific scrutiny ([Kuo et al., 2019][1]). The enzymatic properties of Methioninase and its therapeutic implications are explored, setting the stage for a deeper investigation into its natural sources. The biodiverse Satpura Range, nestled within Hoshangabad District, India, emerges as a prime habitat for novel fungal species. This review underscores the unique ecological conditions of this region, which make it an alluring destination for the screening and isolation of Methioninase-producing fungi. The screening methodologies utilized in isolating these fungal strains, as detailed in studies such as ([Salim et al., 2019][1]) and ([Khalaf and El-Sayed, 2009][2]), are examined in-depth. Additionally, we shed light on the selection criteria employed to identify the most promising strains among this fungal treasure trove. As Methioninase continues to gain prominence in the pharmaceutical arena, the review shifts its focus to the critical area of large-scale production. The importance of upscaling Methioninase production is discussed, and the techniques and strategies employed for achieving this monumental task are outlined.

Keywords: Methioninase, Fungi, Pharmaceutical applications, Screening, Isolation

Edition: Volume 12 Issue 10, October 2023,

Pages: 264 - 270