Downloads: 1 | Views: 116 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Biological Sciences | Azerbaijan | Volume 11 Issue 10, October 2022

Biological Activity of Polyene Antibiotics and Their Use in Improving the Environment

T. C. Pashazade

Abstract: It has been shown that in the complex use of polyene antibiotics with dimethylsulfoxide, the biological activity of antibiotics sharply increases. Comparative physicochemical characteristics of dimethylsulfoxide and polyene antibiotics are presented. Effects of complex interaction of dimethylsulfoxide and polyene antibiotics with bilayer lipid membranes are considered. By the method of bilayer lipid membranes parameters of biological activity of polyene antibiotics are determined. It is shown that amphotericin B and levorin were the most effective among all polyene antibiotics s studied. The results of the dependence of the ionic conductivity of lipid membranes on the concentration of amphotericin B and levorin and on the concentration of cholesterol in membranes are presented. On the basis of polyene antibiotics, effective membrane-active preparation against viral and fungal diseases of plants have been developed.

Keywords: polyene antibiotics, dimethylsulfoxide, amphotericin B, levorin, bilayer lipid membranes, membrane conductivity, viral and fungal diseases of plants

Edition: Volume 11 Issue 10, October 2022,

Pages: 73 - 78