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Research Paper | Pharmacy | Indonesia | Volume 11 Issue 7, July 2022
The Effect of Pasote Breaking Water (Dysphaniaambrosioides L.) on Serum Blood Creatinine Levels of Wistar Rats (Rattus norvegicus)
Yultrina Taghulihi | Dingse Pandiangan [13] | Irma Antasionasti | Nelson Nainggolan [6] | Elvina Artha Nainggolan [3]
Abstract: Pasote plant (Dysphania ambrosioides. L) is a plant that is commonly found in North Sulawesi and has been widely used as herbal medicine. The purpose of this study was to determine blood serum creatinine levels as an indicator of kidney function in the administration of Pasote water extract to Wistar rats (Rattus norvegicus). The method used is the spectrophotometric method. The test animals were grouped into four groups. The normal group was given water, the test group was given 2 g, 4 g, and 8 g of Pasote steeping. The administration of Pasote tea was carried out for 34 days. Rat body weight was measured every day during the treatment and it was seen that a large weight gain occurred in the 2 g treatment group, while the control and 8 g groups showed almost the same growth. The blood serum creatinine test was carried out on days 14, 24 and 34. After measuring for 3 times the average data for the control group was 0.74 mg/dL, the test groups were 0.74 mg/dL, 0.78 mg/dL, and 0.74 mg/dL respectively, where the creatinine levels produced are normal values. These results indicate that the administration of steeping Pasote water for a month has an effect on the weight growth of rats but does not show a significant effect on rat blood serum creatinine levels.
Keywords: Creatinine, Pasote, Dysphania, Kidney, Wistar, Rat
Edition: Volume 11 Issue 7, July 2022,
Pages: 1089 - 1094