International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Chemistry | India | Volume 11 Issue 7, July 2022


Synthesis, Characterization and In Vitro Antimicrobial Evaluation of Some New Benzofuranyl Substituted Pyrido [3, 2-C] Coumarins

Nehakumari N. Gohil | D. I. Brahmbhatt


Abstract: In the present study, a series of benzofuranyl substituted pyrido [3, 2-c] coumarins (4a-l) were synthesized by the reaction of various 4-hydroxycoumarins (1a-c) and appropriate 1- (benzofuran-2-yl) -3-aryl prop-2-en-1-ones (chalcones) (3a-d) under Krohnke?s reaction condition. The structure of all the synthesized compounds elucidated by elemental analysis, IR, 1H-NMR, 13C-APT and some representative mass spectral data. The compounds were subjected to in vitro antimicrobial screening against selected bacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi) and fungal (Candida albicans and Aspergillus niger) pathogens. Compounds 4b, 4e, 4f, 4g, 4i, 4j and 4k displayed excellent antimicrobial activity and served as the most promising leads of the series.


Keywords: Coumarin, benzofuran, antimicrobial screening, broth dilution method, spectral analysis


Edition: Volume 11 Issue 7, July 2022,


Pages: 125 - 132


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