Diagnostic Importance of N-Terminal B-Type Natriuretic Peptide (NT-PRO-BNP)
Abstract: Early clinical diagnosis of heart failure (HF) is challenging because the signs and symptoms are neither sensitive nor specific for diagnosis. The determination of type-B natriuretic peptide (BNP) and its amino terminal fragment N-terminal B-type natriuretic peptide (NT-proBNP) represents an advance in the management of heart failure. The concentration of these molecules strongly reflects ventricular functions and is of prognostic value. BNP and NT-proBNP are cardiac neurohormones secreted from cardiac myocytes in response to cardiac wall stress caused by pressure or volume overload and its release is triggered by physiological and pathological stimuli. There are many randomized trials and systemic reviews conducted over a decade to research the potential value of BNP for diagnosis of HF.
Keywords: BNP, NT-pro BNP, neurohormones, heart failure, natriuretic peptide, biomarker
How to Cite?: Dr. R. Dhananjayan, "Diagnostic Importance of N-Terminal B-Type Natriuretic Peptide (NT-PRO-BNP)", Volume 11 Issue 12, December 2022, International Journal of Science and Research (IJSR), Pages: 727-729, https://www.ijsr.net/getabstract.php?paperid=SR221214152337, DOI: https://dx.doi.org/10.21275/SR221214152337