International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Comparative Studies | Orthopedic | India | Volume 11 Issue 12, December 2022


A Comparative Study on Management of Pain in Patients with Osteoarthritis Receiving Monotherapy of Piroxicam Verses Piroxicam in Combination with Duloxetine

Sara Shreen | Mazharuddinali Khan | Hafsafirdose | Mohammad Yousuf Younus | Syeda Fatima Begum | Syed Majid


Abstract: Osteoarthritis is the most common bone disorder accounting for the majority of long - term disabilities as it usually affects weight - bearing joints such as the cervical, lumbosacral spine, knees, hips, as well as feet. A six - month observational study was conducted in orthopedic outpatient department. Demographic data and other pertinent information were collected. The data was assessed using WOMACS and NPR scale. Group 1 received piroxicam, and group 2 received piroxicam and duloxetine. The mean of patients in Group 1 was (55.16?11.20) and in Group 2 was (58.22?10.62). In comparison of both groups Males (62%) were dominant in group 1 whereas in Group 2 females were dominant (56). The mean height of patients in Group 1 was 5.5?2.00 and in Group 2 was 5.3?1.90. The mean weight of patients in Group 1 was 67.75?11.02 and in Group 2 was 64.2?11.84. Data were assessed using an unpaired t - test. The WOMAC score, NRS rating, and CRP levels of Group B were significantly lower than Group A. When monotherapy with piroxicam fails combination therapy can be used instead of switching to opioids.


Keywords: Comparative, OA, Pain, Piroxicam, Duloxetine


Edition: Volume 11 Issue 12, December 2022,


Pages: 840 - 845


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