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Doctoral Thesis | Pathology | India | Volume 11 Issue 11, November 2022

A Study of P53 Expression and its Correlation with Grades of Oral Squamous Cell Carcinoma

Dr. Ravina Yadav | Dr. Amrit Kalla

Abstract: Aims: this study is an attempt to analyze the proportion of P53 expression among the histopathological samples of oral squamous cell carcinoma received at pathology department, to determine any correlation of P53 expression with grades of OSCC and to determine any relation between expression of P53 with demographic (age, gender) and clinicopathological (location) variables of OSCC. Methodology: it is a cross-sectional study with sample size of 55 patients. Inclusion criteria consisted of specimens who are histologically diagnosed as carcinomas of oral cavity which included biopsies and resection specimen of hemiglossectomy / mandibulectomy with neck dissection. Results and conclusion: most of the patients of oral cavity cancer are males (3:1) and most of the patients were belonging to 6th decade. The most common site of tumor was buccal mucosa (37%) followed by tongue (31%). Majority of the patients (57%) were having moderately differentiated squamous cell carcinoma. 85% of cases were positive for P53 and it was found that P53 expression increases with severity of grades of OSCC that is higher P53 expression in poorly differentiated cases. Hence P53 can be included in the routine immunohistochemistry panel. It was found that the age of patient and grade of tumor had significant correlation and strong association was found with % of immunostaining of P53. Hence, P53 may have predictive and prognostic implications in the squamous cell carcinoma of oral cavity.

Keywords: OSCC, Oral Squamous Cell, Carcinoma

Edition: Volume 11 Issue 11, November 2022,

Pages: 1480 - 1488