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Analysis Study Research Paper | Neurology | India | Volume 11 Issue 11, November 2022
Independent Predictors of Functional Outcome of Acute Stroke among Population of Southern Coastal India - A Hospital Based Prospective Longitudinal Study
Aravinda Mandalapu  | Lanka Gowtam Mukhesh  | Guntupalli Bhavana  | Natuva Sai Sampath Kumar  | Krishnan Ramalingam  | Tirupathe Sunanda  | Natuva Sai Sanjana  | K Natesh Gowtham | Yempati Bhargav  | Mudupula Vemula Sai Sushrutha
Abstract: Introduction: Stroke is the disease of the cerebral blood vessels nourishing the brain. Strokes represent one of the major causes of mortality, functional dependency, and long-term disability in adults. Objective: To determine the parameters predicting the functional outcome at 3 months in acute stroke patients. Materials and Methods: It was a prospective longitudinal study done at Department of Neurology, Narayana Medical college from December 2018 to May 2020. Patients who presented with acute stroke to the Neurology OPD & Emergency Departments were included in the study. Various epidemiological, clinical and investigatory (lab & imaging) variables were studied. All the patients were followed for 3 months after discharge. The functional outcome at 3 months was analysed with reference to all the mentioned variables. Results: Out of the 653 patients, 348 patients (53.29%) were followed up for 3months and analysed. There was a significant difference between patients who had good and poor functional outcome at 3 months as assessed by modified rankin scale (mRS) score with respect to demographic data including age, education, employment and economic state, awareness of vascular risk factors, risk factors including Stroke in young, hypertension, diabetes mellitus, symptom timeline including delay at presentation of more than 4.5 hours, mode of transport to registry hospital, time duration between last known normal to hospital arrival and time duration from ictus to first medical contact, with respect to symptoms at presentation including headache and blurring of vision, examination findings including respiratory rate, Glasgow Coma Scale(GCS) at admission, higher mental function at admission and National Institute of Health stroke scale(NIHSS)score at admission, complications like aspiration pneumonia sepsis and bed sore, time duration for first consult of stroke specialist and duration of hospital stay and with respect to investigations including total count, Neutrophil to lymphocyte ratio, low density lipoprotein cholesterol (LDL) and creatinine. Conclusion: This study observed that high economic state was independently associated with good functional outcome while older age and prolonged duration of history of hypertension, severe grade of GCS at admission, moderate grade of NIHSS score at admission and prolonged duration of hospitalization were found to be independently associated with poor functional outcome.
Keywords: stroke, predictors, functional outcome, mRS
Edition: Volume 11 Issue 11, November 2022,
Pages: 1139 - 1145