Revisiting the Roles of IL-17 in Colorectal Cancer

Larissa Volpini Cardoso, Gustavo Gabriel Zonaro, Barbara Nunes da Silva, Giulia Frederico, Vinicius Barbieri Lanfredi, Leandro Minatel Vidal de Negreiros, Sergio Luiz Pinheiro, Raquel Franco Leal, Giovanna Rosa Degasperi

Abstract: Colorectal cancer is an important contributor to cancer-associated mortality and morbidity in developed countries. Inflammation is an important factor that leads to the development of colorectal cancer and several inflammatory cytokines are associated with the development of this type of tumor. The interleukin-17 (IL-17), a pleiotropic proinflammatory cytokine, can promote cancer-induced inflammation by recruiting monocytes and neutrophils to the site of inflammation. In this review, we are dedicated to summarizing and revisiting the main aspects related to colorectal cancer and the role of IL-17 in this scenario.

Keywords: colorectal cancer, inflammation, IL-17