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Masters Thesis | Anaesthesiology | India | Volume 11 Issue 11, November 2022

Comparison of Efficacy of Pre-Operative Oral Pregabalin versus Oral Gabapentin on Postoperative Analgesia in Patients undergoing Lower Abdominal Surgeries under Spinal Anaesthesia : A Prospective, Randomized, Controlled Study

K. K. Arora | Ritu Pauranik | Malathi Bhaskar

Abstract: Objective: Our aim was to compare post-operative analgesic potency of oral pregabalin 150mg and gabapentin 600mg administered pre-operatively in patients subjected to lower abdominal surgeries under sub-arachnoid block (SAB). Methods: 90 patients posted for lower abdominal surgery under SAB were randomly allocated to three groups - P, G and C with thirty patients in each group. Cap.Pregabalin 150 mg was administered to Group P (Pregabalin group), Cap. Gabapentin 600mg to Group G (Gabapentin group) and Cap.vitamin B complex to Group C (control group) 1 hour before surgery. Our primary objective was to record time to first rescue analgesic (IV Diclofenac 75mg) requirement and total analgesic consumption 24 hours post-operatively. Results: Post-operatively, Time to first rescue analgesic requirement was Group P > Group G > Group C [9h 19 min ? 3h 50min, 6h 12min ? 3h 52min, 4h ? 1h 39min, respectively (P = 0.001)] and mean rescue analgesic requirement was also Group P > Group G > Group C. Group P showed highest time to two-segment regression of sensory blockade, stable post-operative hemodynamic status and minimal adverse effects. Conclusion: Pregabalin has a better pre-emptive analgesic profile in comparison with Gabapentin.

Keywords: Pregabalin, Gabapentin, lower abdominal surgeries, post-operative analgesia, pre-emptive analgesia

Edition: Volume 11 Issue 11, November 2022,

Pages: 542 - 546