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Research Paper | Toxicology Science | India | Volume 11 Issue 1, January 2022
Histopathological Changes in the Intestine and Testis of Mice Treated with 2,3,7,8 TCDD
J. Jigyasi | S. Chauhan [6] | J. Savani | R. Kundu
Abstract: 2, 3, 7, 8 TCDD being a very hazardous persistent organic pollutant which having less biodegradable and high biomagnification capacity to different trophic level. The aim of the present study was to evaluate the toxicological effects of sublethal dose of TCDD exposed for subacute duration which causes alteration in cellular activity of intestine and testis of mice. Three groups of mice were treated individually, receiving corn oil vehicle, TCDD 4?g/kgbw/d and TCDD 40?g/kgbw/d respectively for 7,14 and 21 days of exposure duration. On the scheduled days selected tissues were excised, cleaned and blocks were prepared for the analysis of histopathological effects. The results suggested that increased dose of TCDD causes drastic changes in villi and cryptic cells of intestine. Increased goblet cells in intestinal cells are providing protective mechanism for the pathological changes created by TCDD. Similar degeneration was observed in testicular germinal epithelium and morphological changes in primary spermatocyte and spermatid. Increased dose of TCDD (40?g/kgbw/d) exposed for higher exposure duration (21 days) causes degenerative changes in testicular and intestinal cells.
Keywords: Dose and Duration, Intestine, Testis, Histopathology, TCDD toxicity
Edition: Volume 11 Issue 1, January 2022,
Pages: 520 - 525