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Research Paper | Genomic Sciences and Bioinformatics | India | Volume 11 Issue 10, October 2022

Investigating Stability of a Mutant Version of the REG3A Protein using FoldX and PIC

Aryan Prakash

Abstract: Quantitative analysis of stability of proteins due to different versions - the mutant and wild type versions - of the same gene would give us insight into the possible physiological effects of the particular mutation. This analysis was carried out using online tools such as PIC server and FoldX. The stability of REG3A protein and its mutant versions were compared to find that the mutant version due the replacement of nucleotide C with nucleotide T was a stable protein relative to the wild type REG3A.

Keywords: Protein stablity, mutant protein, wild-type protein, Gibbs free energy, mutations

Edition: Volume 11 Issue 10, October 2022,

Pages: 1152 - 1153