COVID-19 Related Potential Multisystem Inflammatory Syndrome in a Neonate (MIS - N)

Sachin A Shah, Poojan R Patel

Abstract: A 28 weeks preterm, male baby, 1.050 kg of birth weight born to COVID positive mother presented with cardiogenic shock and respiratory distress with clinical and laboratory features of multisystem inflammatory syndrome in neonate. Baby was anti - SARS cov - 2 IgG positive with negative COVID-19 RTPCR. Vertical transmission of SARS - Coronavirus - 2 (SARS - CoV - 2) to the newborn has been noted in the current SARS - CoV - 2 pandemic. A meta - analysis of 176 papers documenting confirmed neonatal SARS - CoV - 2 infections reported that 30% were due to vertical transmission and that 55% of infected neonates developed COVID-19 symptoms [1]. Case reports and series have described transplacental transfer of maternal IgG antibodies, possibly with a protective effect [2, 3, 4, 5]. We report a potential case of multisystem inflammatory syndrome in childhood from tertiary care center - Anand children hospital, Surat, Gujarat, India in a neonate initially presenting with features of cardiogenic shock.

Keywords: neonatal MIS - C, neonates, COVID-19