Microwave Assisted Synthesis and Thermal Behavior Study of a Compound Containing 1, 3, 4 - Oxadiazole Rings

Varsha V. Thorat

Abstract: 1, 3 - bis [5 - (3 - methoxy - 4 - hydroxyphenyl) - 1, 3, 4 - oxadiazol - 2 - yl]propane was synthesized in two steps. In the first step, glutaric acid dihydrazide was condensed with vanillin (aldehyde) to yield the corresponding dihydrazone. The dihydrazone on oxidative cyclisation gave the corresponding bis - 1, 3, 4 - oxadiazole. Chloramine - T was employed as a reagent for oxidative cyclising. The oxidative cyclisation step was carried under microwave irradiation. The synthesized compound was characterized by FTIR and NMR spectroscopy. Further thermogravimetric analysis was done to study the thermal stability of the synthesized product. The study reveals that oxidative transformation under microwave irradiation is very clean, rapid and the reaction conditions and the work up procedures are simple and mild.

Keywords: bis - 1, 3, 4 - oxadiazole, chloramine - T, dihydrazone, microwave irradiation